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Oscillatory stimuli differentiate adapting circuit topologies

Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewir...

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Detalles Bibliográficos
Autores principales: Rahi, Sahand Jamal, Larsch, Johannes, Pecani, Kresti, Katsov, Alexander Y., Mansouri, Nahal, Tsaneva-Atanasova, Krasimira, Sontag, Eduardo D., Cross, Frederick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623142/
https://www.ncbi.nlm.nih.gov/pubmed/28846089
http://dx.doi.org/10.1038/nmeth.4408