Oscillatory stimuli differentiate adapting circuit topologies

Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewir...

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Detalles Bibliográficos
Autores principales: Rahi, Sahand Jamal, Larsch, Johannes, Pecani, Kresti, Katsov, Alexander Y., Mansouri, Nahal, Tsaneva-Atanasova, Krasimira, Sontag, Eduardo D., Cross, Frederick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623142/
https://www.ncbi.nlm.nih.gov/pubmed/28846089
http://dx.doi.org/10.1038/nmeth.4408
Descripción
Sumario:Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewiring we identified the circuit dominating cell cycle timing in yeast. In C. elegans AWA neurons we uncovered a Ca2+-NFL, diffcult to find by other means, especially in wild-type, intact animals. (70 words)

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