Oscillatory stimuli differentiate adapting circuit topologies

Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewir...

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Autores principales: Rahi, Sahand Jamal, Larsch, Johannes, Pecani, Kresti, Katsov, Alexander Y., Mansouri, Nahal, Tsaneva-Atanasova, Krasimira, Sontag, Eduardo D., Cross, Frederick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623142/
https://www.ncbi.nlm.nih.gov/pubmed/28846089
http://dx.doi.org/10.1038/nmeth.4408
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author Rahi, Sahand Jamal
Larsch, Johannes
Pecani, Kresti
Katsov, Alexander Y.
Mansouri, Nahal
Tsaneva-Atanasova, Krasimira
Sontag, Eduardo D.
Cross, Frederick R.
author_facet Rahi, Sahand Jamal
Larsch, Johannes
Pecani, Kresti
Katsov, Alexander Y.
Mansouri, Nahal
Tsaneva-Atanasova, Krasimira
Sontag, Eduardo D.
Cross, Frederick R.
author_sort Rahi, Sahand Jamal
collection PubMed
description Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewiring we identified the circuit dominating cell cycle timing in yeast. In C. elegans AWA neurons we uncovered a Ca2+-NFL, diffcult to find by other means, especially in wild-type, intact animals. (70 words)
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spelling pubmed-56231422018-02-28 Oscillatory stimuli differentiate adapting circuit topologies Rahi, Sahand Jamal Larsch, Johannes Pecani, Kresti Katsov, Alexander Y. Mansouri, Nahal Tsaneva-Atanasova, Krasimira Sontag, Eduardo D. Cross, Frederick R. Nat Methods Article Adapting pathways consist of negative feedback loops (NFLs) or incoherent feedforward loops (IFFLs), which we show can be differentiated using oscillatory stimulation: NFLs but not IFFLs generically show ‘refractory period stabilization’ or ‘period skipping’. Using these signatures and genetic rewiring we identified the circuit dominating cell cycle timing in yeast. In C. elegans AWA neurons we uncovered a Ca2+-NFL, diffcult to find by other means, especially in wild-type, intact animals. (70 words) 2017-08-28 2017-10 /pmc/articles/PMC5623142/ /pubmed/28846089 http://dx.doi.org/10.1038/nmeth.4408 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Rahi, Sahand Jamal
Larsch, Johannes
Pecani, Kresti
Katsov, Alexander Y.
Mansouri, Nahal
Tsaneva-Atanasova, Krasimira
Sontag, Eduardo D.
Cross, Frederick R.
Oscillatory stimuli differentiate adapting circuit topologies
title Oscillatory stimuli differentiate adapting circuit topologies
title_full Oscillatory stimuli differentiate adapting circuit topologies
title_fullStr Oscillatory stimuli differentiate adapting circuit topologies
title_full_unstemmed Oscillatory stimuli differentiate adapting circuit topologies
title_short Oscillatory stimuli differentiate adapting circuit topologies
title_sort oscillatory stimuli differentiate adapting circuit topologies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623142/
https://www.ncbi.nlm.nih.gov/pubmed/28846089
http://dx.doi.org/10.1038/nmeth.4408
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