chromVAR: Inferring transcription factor-associated accessibility from single-cell epigenomic data

Single cell ATAC-seq (scATAC) yields sparse data that makes application of conventional analysis approaches challenging. We developed chromVAR, an R package for analyzing sparse chromatin accessibility data by estimating gain or loss of accessibility within peaks sharing the same motif or annotation...

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Detalles Bibliográficos
Autores principales: Schep, Alicia N., Wu, Beijing, Buenrostro, Jason D., Greenleaf, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623146/
https://www.ncbi.nlm.nih.gov/pubmed/28825706
http://dx.doi.org/10.1038/nmeth.4401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623146/
https://www.ncbi.nlm.nih.gov/pubmed/28825706
http://dx.doi.org/10.1038/nmeth.4401

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