The Role of Canonical and Non-Canonical Hedgehog Signaling in Tumor Progression in a Mouse Model of Small Cell Lung Cancer

Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh signaling is mediated by Hh ligand binding to the receptor Patched (Ptch), which in turn activates Gli-mediated transcription through Smoothened (Smo), the molecular target of the Hh pathway inhibito...

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Detalles Bibliográficos
Autores principales: Szczepny, Anette, Rogers, Samuel, Jayasekara, W. Samantha N., Park, Kwon, McCloy, Rachael A., Cochrane, Catherine R., Ganju, Vinod, Cooper, Wendy A., Sage, Julien, Peacock, Craig D., Cain, Jason E., Burgess, Andrew, Watkins, D. Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623150/
https://www.ncbi.nlm.nih.gov/pubmed/28581526
http://dx.doi.org/10.1038/onc.2017.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623150/
https://www.ncbi.nlm.nih.gov/pubmed/28581526
http://dx.doi.org/10.1038/onc.2017.173

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