Cargando…

Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma

Most hepatocellular carcinomas (HCC) develop as a result of chronic liver inflammation. We have shown that the oncoprotein gankyrin is critical for inflammation‐induced tumorigenesis in the colon. Although the in vitro function of gankyrin is well known, its role in vivo remains to be elucidated. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakurai, Toshiharu, Yada, Norihisa, Hagiwara, Satoru, Arizumi, Tadaaki, Minaga, Kosuke, Kamata, Ken, Takenaka, Mamoru, Minami, Yasunori, Watanabe, Tomohiro, Nishida, Naoshi, Kudo, Masatoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623735/ https://www.ncbi.nlm.nih.gov/pubmed/28777492 http://dx.doi.org/10.1111/cas.13341

Ejemplares similares

Comparison of systems for assessment of post-therapeutic response to sorafenib for hepatocellular carcinoma
por: Arizumi, Tadaaki, et al.
Publicado: (2014)

Cold-inducible RNA-binding protein promotes the development of liver cancer
por: Sakurai, Toshiharu, et al.
Publicado: (2015)

Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy
por: Nishida, Naoshi, et al.
Publicado: (2018)

The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3
por: Sakurai, Toshiharu, et al.
Publicado: (2017)

Unique Association between Global DNA Hypomethylation and Chromosomal Alterations in Human Hepatocellular Carcinoma
por: Nishida, Naoshi, et al.
Publicado: (2013)

Dysbiosis-Associated Polyposis of the Colon—Cap Polyposis
por: Okamoto, Kazuki, et al.
Publicado: (2018)

Clinical Safety and Efficacy of Secondary Prophylactic Pegylated G-CSF in Advanced Pancreatic Cancer Patients Treated with mFOLFIRINOX: A Single-center Retrospective Study
por: Yamao, Kentaro, et al.
Publicado: (2019)

Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent
por: Kamata, Ken, et al.
Publicado: (2017)

Cystic duct antegrade stenting for cholangitis after the long-term deployment of lumen-apposing metal stents for calculous cholecystitis
por: Kamata, Ken, et al.
Publicado: (2018)

Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-associated Inflammatory Bowel Disease
por: Kono, Masashi, et al.
Publicado: (2019)

Efficacy and Safety of Chemotherapy Following Anti-PD-1 Antibody Therapy for Gastric Cancer: A Case of Sclerosing Cholangitis
por: Kono, Masashi, et al.
Publicado: (2019)

Acute Pancreatitis with Disturbed Consciousness Caused by Hyperparathyroidism
por: Otsuka, Yasuo, et al.
Publicado: (2018)

Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Study
por: Ueshima, Kazuomi, et al.
Publicado: (2019)

Bispectral index-guided propofol sedation during endoscopic ultrasonography
por: Okamoto, Ayana, et al.
Publicado: (2022)

Verrucous antral gastritis in relation to Helicobacter pylori infection, nutrition, and gastric atrophy
por: Tsuji, Naoko, et al.
Publicado: (2019)

Artificial intelligence-based endoscopic diagnosis of colorectal polyps using residual networks
por: Komeda, Yoriaki, et al.
Publicado: (2021)

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis
por: Hagiwara, Satoru, et al.
Publicado: (2017)

Deficiency of Gankyrin in the small intestine is associated with augmented colitis accompanied by altered bacterial composition of intestinal microbiota
por: Sakurai, Toshiharu, et al.
Publicado: (2020)

Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection
por: Komeda, Yoriaki, et al.
Publicado: (2019)

Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire
por: Takashima, Kota, et al.
Publicado: (2021)

Lenvatinib as an Initial Treatment in Patients with Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven Criteria and Child–Pugh A Liver Function: A Proof-Of-Concept Study
por: Kudo, Masatoshi, et al.
Publicado: (2019)

Usefulness of the Novel Snare-over-the-Guidewire Method for Transpapillary Plastic Stent Replacement (with Video)
por: Yoshida, Akihiro, et al.
Publicado: (2021)

Achievement of long-term stent patency in endoscopic ultrasonography-guided right bile duct drainage after left hepatic lobectomy (with video)
por: Minaga, Kosuke, et al.
Publicado: (2017)

Erythropoietic Protoporphyria-related Hepatopathy Successfully Treated with Phlebotomy
por: Yoshida, Akihiro, et al.
Publicado: (2018)

Clinicopathological analysis of hepatic immune-related adverse events in comparison with autoimmune hepatitis and graft-versus host disease
por: Hagiwara, Satoru, et al.
Publicado: (2021)

Comparison of Radiation Exposure between Endoscopic Ultrasound-Guided Hepaticogastrostomy and Hepaticogastrostomy with Antegrade Stenting
por: Takenaka, Mamoru, et al.
Publicado: (2022)

Diagnostic Value of EUS-Guided Fine-Needle Aspiration Biopsy for Gastric Linitis Plastica with Negative Endoscopic Biopsy
por: Takada, Ryutaro, et al.
Publicado: (2021)

A case of small invasive gastric cancer arising from Helicobacter pylori‐negative gastric mucosa: Fundic gland‐type adenocarcinoma
por: Komeda, Yoriaki, et al.
Publicado: (2017)

Cases with Refractory Ascites and a Delayed Response to Tolvaptan
por: Hagiwara, Satoru, et al.
Publicado: (2016)

Imaging Diagnosis of Various Hepatocellular Carcinoma Subtypes and Its Hypervascular Mimics: Differential Diagnosis Based on Conventional Interpretation and Artificial Intelligence
por: Minami, Yasunori, et al.
Publicado: (2022)

A novel teaching tool for visualizing the invisible bile duct axis in 3 dimensions during biliary cannulation (Compact Disc method)
por: Takenaka, Mamoru, et al.
Publicado: (2020)

Usefulness of detective flow imaging endoscopic ultrasound for the diagnosis of rectal wall thickening
por: Masuta, Yasuhiro, et al.
Publicado: (2023)

Advances in Immunotherapy for Hepatocellular Carcinoma
por: Hagiwara, Satoru, et al.
Publicado: (2023)

Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review
por: Minaga, Kosuke, et al.
Publicado: (2018)

Recent Updates on the Relationship between Cancer and Autoimmune Pancreatitis
por: Okamoto, Ayana, et al.
Publicado: (2019)

IL-33 as a Critical Cytokine for Inflammation and Fibrosis in Inflammatory Bowel Diseases and Pancreatitis
por: Kurimoto, Masayuki, et al.
Publicado: (2021)

RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases
por: Honjo, Hajime, et al.
Publicado: (2021)

Pancreatic colonization of fungi in the development of severe acute pancreatitis
por: Otsuka, Yasuo, et al.
Publicado: (2022)

Activation of NOD1 and NOD2 in the development of liver injury and cancer
por: Omaru, Naoya, et al.
Publicado: (2022)

Pancreatic neuroendocrine carcinoma with unique morphological features mimicking intraductal papillary mucinous carcinoma: A case report
por: Tanaka, Hidekazu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6dhi394nm4f7jegkh3bp2o5ro3