Thwarting endogenous stress: BRCA protects against aldehyde toxicity

Homologous recombination (HR) and the Fanconi Anemia (FA) pathways constitute essential repair pathways for DNA damage, which includes DNA double‐stranded breaks (DSB) and inter‐strand cross‐links (ICL), respectively. Germline mutations affecting a single copy of the HR factors BRCA1 and BRCA2 predi...

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Detalles Bibliográficos
Autores principales: Ray Chaudhuri, Arnab, Nussenzweig, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623899/
https://www.ncbi.nlm.nih.gov/pubmed/28835508
http://dx.doi.org/10.15252/emmm.201708194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623899/
https://www.ncbi.nlm.nih.gov/pubmed/28835508
http://dx.doi.org/10.15252/emmm.201708194

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