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Spatial distribution of disease-associated variants in three-dimensional structures of protein complexes
Next-generation sequencing enables simultaneous analysis of hundreds of human genomes associated with a particular phenotype, for example, a disease. These genomes naturally contain a lot of sequence variation that ranges from single-nucleotide variants (SNVs) to large-scale structural rearrangement...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623905/ https://www.ncbi.nlm.nih.gov/pubmed/28945216 http://dx.doi.org/10.1038/oncsis.2017.79 |