Xanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma

Xanthine dehydrogenase (XDH), a rate-limiting enzyme involved in purine metabolism, has an essential role in inflammatory cascades. Researchers have known for decades that XDH activity is decreased in some cancers, including hepatocellular carcinoma (HCC). However, the role of XDH in cancer pathogen...

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Detalles Bibliográficos
Autores principales: Chen, G-L, Ye, T, Chen, H-L, Zhao, Z-Y, Tang, W-Q, Wang, L-S, Xia, J-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623907/
https://www.ncbi.nlm.nih.gov/pubmed/28945217
http://dx.doi.org/10.1038/oncsis.2017.81

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623907/
https://www.ncbi.nlm.nih.gov/pubmed/28945217
http://dx.doi.org/10.1038/oncsis.2017.81

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