Cargando…

DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP

The expression of clock genes ARNTL2, NPAS2 and DEC2 are disturbed in rheumatoid arthritis, an autoimmune disease with circadian variation of symptoms. We have shown that TNF is a potent inducer of these genes. We investigated the regulation of ARNTL2 and NPAS2 by TNF and elucidated their effect on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olkkonen, Juri, Kouri, Vesa-Petteri, Kuusela, Elina, Ainola, Mari, Nordström, Dan, Eklund, Kari K., Mandelin, Jami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ubiquity Press 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624067/ https://www.ncbi.nlm.nih.gov/pubmed/30210560 http://dx.doi.org/10.5334/jcr.149

Ejemplares similares

Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis
por: Olkkonen, Juri, et al.
Publicado: (2015)

IL-17A and TNF synergistically drive expression of proinflammatory mediators in synovial fibroblasts via IκBζ-dependent induction of ELF3
por: Kouri, Vesa-Petteri, et al.
Publicado: (2022)

Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level
por: Kouri, Vesa-Petteri, et al.
Publicado: (2013)

ARNTL (BMAL1) and NPAS2 Gene Variants Contribute to Fertility and Seasonality
por: Kovanen, Leena, et al.
Publicado: (2010)

NPAS2 and PER2 are linked to risk factors of the metabolic syndrome
por: Englund, Ani, et al.
Publicado: (2009)

Bioinformatic analysis of genetic changes CLOCK, BMAL1, CRY1, CRY2, PER1, PER2, PER3, and NPAS2 proteins in HCC patients
por: Ayan, Durmus, et al.
Publicado: (2023)

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures
por: Parsons, Michael J, et al.
Publicado: (2014)

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese
por: Gu, Zhuqin, et al.
Publicado: (2015)

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family
por: Sun, Xiangnan, et al.
Publicado: (2022)

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators
por: Landgraf, Dominic, et al.
Publicado: (2016)

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
por: Ozburn, Angela R., et al.
Publicado: (2017)

The Impact of the Circadian Genes CLOCK and ARNTL on Myocardial Infarction
por: Škrlec, Ivana, et al.
Publicado: (2020)

The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation
por: Wang, Xingzhi, et al.
Publicado: (2021)

Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology
por: Murgo, Emanuele, et al.
Publicado: (2023)

DEC2–E4BP4 Heterodimer Represses the Transcriptional Enhancer Activity of the EE Element in the Per2 Promoter
por: Tanoue, Shintaro, et al.
Publicado: (2015)

ARNTL2 is a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Triple-Negative Breast Cancer
por: Wang, Xiaoyu, et al.
Publicado: (2021)

Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma
por: Wang, Song, et al.
Publicado: (2021)

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma
por: Zhang, Huan, et al.
Publicado: (2022)

ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis
por: Wang, Tao, et al.
Publicado: (2023)

DEC1 and DEC2 Crosstalk between Circadian Rhythm and Tumor Progression
por: Sato, Fuyuki, et al.
Publicado: (2016)

Isolation and Characterization of Chicken NPAS3
por: Shin, Jiheon, et al.
Publicado: (2010)

Molecular characterisation of rare loss-of-function NPAS3 and NPAS4 variants identified in individuals with neurodevelopmental disorders
por: Rossi, Joseph J., et al.
Publicado: (2021)

The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer
por: Ha, Ngoc-Han, et al.
Publicado: (2016)

ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P(2) exchange
por: Takahashi, Kohta, et al.
Publicado: (2021)

Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing
por: Shibuya, Yoichiro, et al.
Publicado: (2022)

NPAS2 promotes cell survival of hepatocellular carcinoma by transactivating CDC25A
por: Yuan, Peng, et al.
Publicado: (2017)

The circadian transcription factor ARNTL2 is regulated by weight-loss interventions in human white adipose tissue and inhibits adipogenesis
por: Mandl, Markus, et al.
Publicado: (2022)

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function
por: Bersten, David C., et al.
Publicado: (2014)

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
por: Lavtar, Polona, et al.
Publicado: (2018)

Polymorphisms in ARNTL/BMAL1 and CLOCK Are Not Associated with Multiple Sclerosis in Spanish Population
por: de Rojas, Isabel, et al.
Publicado: (2022)

Town-Council Proceedings.—Dec. 2, 1856
por: Alison, W. P.
Publicado: (1857)

Sex‐specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia
por: Puig, Stephanie, et al.
Publicado: (2022)

Characterization of molecular subtypes based on chromatin regulators and identification of the role of NPAS2 in lung adenocarcinoma
por: Huang, Yongbiao, et al.
Publicado: (2023)

Genetic Variation in Circadian Rhythm Genes CLOCK and ARNTL as Risk Factor for Male Infertility
por: Hodžić, Alenka, et al.
Publicado: (2013)

Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair
por: Watanabe, Aiko, et al.
Publicado: (2023)

SAT-234 DBP Gene Polymorphisms in Adult and Postmenopausal Women: Association with DBP and Vitamin D Serum Levels
por: Santos, Betânia, et al.
Publicado: (2019)

NPAS3 variants in schizophrenia: a neuroimaging study
por: Bernier, Denise, et al.
Publicado: (2014)

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia
por: Choy, Fong Chan, et al.
Publicado: (2015)

Structural insights and characterization of human Npas4 protein
por: Fahim, Ammad, et al.
Publicado: (2018)

Molecular analysis of NPAS3 functional domains and variants
por: Luoma, Leiah M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pf0c91083oshqouv5q6uao8cqr