Mitochondrial permeabilisation engages NF-κB dependent anti-tumour activity under caspase deficiency

Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilisation (MOMP) typically kills cells even in the absence of caspase activity. Caspase activity can also have a variety of unwanted consequences that include DNA-damage. We t...

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Detalles Bibliográficos
Autores principales: Giampazolias, Evangelos, Zunino, Barbara, Dhayade, Sandeep, Bock, Florian, Cloix, Catherine, Cao, Kai, Roca, Alba, Lopez, Jonathan, Ichim, Gabriel, Proïcs, Emma, Rubio-Patiño, Camila, Fort, Loic, Yatim, Nader, Woodham, Emma, Orozco, Susana, Taraborrelli, Lucia, Peltzer, Nieves, Lecis, Daniele, Machesky, Laura, Walczak, Henning, Albert, Matthew L., Milling, Simon, Oberst, Andrew, Ricci, Jean-Ehrland, Ryan, Kevin M., Blyth, Karen, Tait, Stephen W.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624512/
https://www.ncbi.nlm.nih.gov/pubmed/28846096
http://dx.doi.org/10.1038/ncb3596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624512/
https://www.ncbi.nlm.nih.gov/pubmed/28846096
http://dx.doi.org/10.1038/ncb3596

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