The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

The P2X7 receptor mediates extracellular ATP signaling implicated in the development of devastating diseases such as chronic pain and cancer. Activation of the P2X7 receptor leads to opening of the characteristic dye-permeable membrane pore for molecules up to ~900 Da. However, it remains controvers...

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Detalles Bibliográficos
Autores principales: Karasawa, Akira, Michalski, Kevin, Mikhelzon, Polina, Kawate, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624784/
https://www.ncbi.nlm.nih.gov/pubmed/28920575
http://dx.doi.org/10.7554/eLife.31186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624784/
https://www.ncbi.nlm.nih.gov/pubmed/28920575
http://dx.doi.org/10.7554/eLife.31186

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