Cargando…

Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism

Transforming Growth Factor beta (TGF-β) induces tumor cell migration and invasion. However, its role in inducing metabolic reprogramming is poorly understood. Here we analyzed the metabolic profile of hepatocellular carcinoma (HCC) cells that show differences in TGF-β expression. Oxygen consumption...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soukupova, Jitka, Malfettone, Andrea, Hyroššová, Petra, Hernández-Alvarez, María-Isabel, Peñuelas-Haro, Irene, Bertran, Esther, Junza, Alexandra, Capellades, Jordi, Giannelli, Gianluigi, Yanes, Oscar, Zorzano, Antonio, Perales, José Carlos, Fabregat, Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624948/ https://www.ncbi.nlm.nih.gov/pubmed/28970582 http://dx.doi.org/10.1038/s41598-017-12837-y

Ejemplares similares

Epithelial–Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism
por: Soukupova, Jitka, et al.
Publicado: (2021)

Resminostat induces changes in epithelial plasticity of hepatocellular carcinoma cells and sensitizes them to sorafenib-induced apoptosis
por: Soukupova, Jitka, et al.
Publicado: (2017)

New Insights into the Crossroads between EMT and Stemness in the Context of Cancer
por: Fabregat, Isabel, et al.
Publicado: (2016)

Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression
por: Rani, Bhavna, et al.
Publicado: (2018)

The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
por: Herranz-Itúrbide, Macarena, et al.
Publicado: (2021)

Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-β-induced epithelial to amoeboid transition
por: López-Luque, Judit, et al.
Publicado: (2019)

Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
por: Bueno, Maria J., et al.
Publicado: (2019)

Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma
por: Espinosa-Sotelo, Rut, et al.
Publicado: (2023)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
por: Peñuelas‐Haro, Irene, et al.
Publicado: (2023)

Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma
por: Dituri, Francesco, et al.
Publicado: (2022)

LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity
por: Bertran, Laia, et al.
Publicado: (2023)

LC/MS-Based Untargeted Metabolomics Analysis in Women with Morbid Obesity and Associated Type 2 Diabetes Mellitus
por: Auguet, Teresa, et al.
Publicado: (2023)

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation
por: Valera-Alberni, Miriam, et al.
Publicado: (2021)

Vitamin B(12) is a limiting factor for induced cellular plasticity and tissue repair
por: Kovatcheva, Marta, et al.
Publicado: (2023)

Redundant roles of the phosphatidate phosphatase family in triacylglycerol synthesis in human adipocytes
por: Temprano, Ana, et al.
Publicado: (2016)

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
por: Fabregat, Isabel, et al.
Publicado: (2018)

Calcium Regulates HCC Proliferation as well as EGFR Recycling/Degradation and Could Be a New Therapeutic Target in HCC
por: Modica, Teresa Maria Elisa, et al.
Publicado: (2019)

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
por: Caja, Laia, et al.
Publicado: (2018)

Positional Enrichment by Proton Analysis (PEPA): A One‐Dimensional (1)H‐NMR Approach for (13)C Stable Isotope Tracer Studies in Metabolomics
por: Vinaixa, Maria, et al.
Publicado: (2017)

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors
por: Lahiguera, Álvaro, et al.
Publicado: (2020)

Plasma Metabolomic Profiling Associates Bicuspid Aortic Valve Disease and Ascending Aortic Dilation with a Decrease in Antioxidant Capacity †
por: Martínez-Micaelo, Neus, et al.
Publicado: (2020)

CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression
por: Cano-Crespo, Sara, et al.
Publicado: (2019)

Direct and Indirect Effect of TGFβ on Treg Transendothelial Recruitment in HCC Tissue Microenvironment
por: Dituri, Francesco, et al.
Publicado: (2021)

CliqueMS: a computational tool for annotating in-source metabolite ions from LC-MS untargeted metabolomics data based on a coelution similarity network
por: Senan, Oriol, et al.
Publicado: (2019)

The Tumor Microenvironment Drives Intrahepatic Cholangiocarcinoma Progression
por: Mancarella, Serena, et al.
Publicado: (2022)

The level of caveolin-1 expression determines response to TGF-β as a tumour suppressor in hepatocellular carcinoma cells
por: Moreno-Càceres, Joaquim, et al.
Publicado: (2017)

Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca(2+)
por: Moreno-Felici, Juan, et al.
Publicado: (2019)

Correction: Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II
por: Dituri, Francesco, et al.
Publicado: (2013)

Mitochondrial Dynamics and Liver Cancer
por: Hernández-Alvarez, María Isabel, et al.
Publicado: (2021)

A novel empeROR of pancreatic malignancy
por: Peñuelas‐Haro, Irene, et al.
Publicado: (2023)

2-[(18)F]FDG PET/CT as a Predictor of Microvascular Invasion and High Histological Grade in Patients with Hepatocellular Carcinoma
por: Sabaté-Llobera, Aida, et al.
Publicado: (2021)

Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II
por: Dituri, Francesco, et al.
Publicado: (2013)

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells
por: Hyroššová, Petra, et al.
Publicado: (2022)

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions
por: Plana-Bonamaisó, Anna, et al.
Publicado: (2020)

Transforming Growth Factor-β Promotes Morphomechanical Effects Involved in Epithelial to Mesenchymal Transition in Living Hepatocellular Carcinoma
por: Cascione, Mariafrancesca, et al.
Publicado: (2018)

A Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data
por: Vinaixa, Maria, et al.
Publicado: (2012)

MCF-7 Drug Resistant Cell Lines Switch Their Lipid Metabolism to Triple Negative Breast Cancer Signature
por: Adriá-Cebrián, Jose, et al.
Publicado: (2021)

PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner
por: Hyroššová, Petra, et al.
Publicado: (2021)

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Correction: Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
por: Centonze, Matteo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aire1l1vo9cnh6lddbqs7d7c7q