Pharmacological hypothesis: Nitric oxide‐induced inhibition of ADAM‐17 activity as well as vesicle release can in turn prevent the production of soluble endothelin‐converting enzyme

Endothelin‐1 (ET‐1) and nitric oxide (NO) are two highly potent vasoactive molecules with opposing effects on the vasculature. Endothelin‐converting enzyme (ECE) and nitric oxide synthase (NOS) catalyse the production of ET‐1 and NO, respectively. It is well established that these molecules play a c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuruppu, Sanjaya, Rajapakse, Niwanthi W., Parkington, Helena C., Smith, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625149/
https://www.ncbi.nlm.nih.gov/pubmed/28971608
http://dx.doi.org/10.1002/prp2.335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625149/
https://www.ncbi.nlm.nih.gov/pubmed/28971608
http://dx.doi.org/10.1002/prp2.335

Ejemplares similares