Coffee inhibition of CYP3A4 in vitro was not translated to a grapefruit‐like pharmacokinetic interaction clinically

Grapefruit can augment oral medication bioavailability through irreversible (mechanism‐based) inhibition of intestinal CYP3A4. Supplementary data from our recent coffee–drug interaction clinical study showed some subjects had higher area under the plasma drug concentration ‐ time curve (AUC) and pla...

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Detalles Bibliográficos
Autores principales: Dresser, George K., Urquhart, Brad L., Proniuk, Julianne, Tieu, Alvin, Freeman, David J., Arnold, John Malcolm, Bailey, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625156/
https://www.ncbi.nlm.nih.gov/pubmed/28971609
http://dx.doi.org/10.1002/prp2.346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625156/
https://www.ncbi.nlm.nih.gov/pubmed/28971609
http://dx.doi.org/10.1002/prp2.346

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