Cargando…
Coffee inhibition of CYP3A4 in vitro was not translated to a grapefruit‐like pharmacokinetic interaction clinically
Grapefruit can augment oral medication bioavailability through irreversible (mechanism‐based) inhibition of intestinal CYP3A4. Supplementary data from our recent coffee–drug interaction clinical study showed some subjects had higher area under the plasma drug concentration ‐ time curve (AUC) and pla...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625156/ https://www.ncbi.nlm.nih.gov/pubmed/28971609 http://dx.doi.org/10.1002/prp2.346 |