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An integrin antagonist (MK‐0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model

Multiple integrins have been implicated in modulating renal function. Modulation of integrin function can lead to pathophysiological processes associated with diabetic nephropathy such as alterations in the glomerular filtration barrier and kidney fibrosis. The complexity of these pathophysiological...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoyan, Zhang, Ji, Haimbach, Robin, Zhu, Wei, Mayer‐Ezell, Rosemary, Garcia‐Calvo, Margarita, Smith, Elizabeth, Price, Olga, Kan, Yanqing, Zycband, Emanuel, Zhu, Yonghua, Hoek, Maarten, Cox, Jason M., Ma, Lijun, Kelley, David E., Pinto, Shirly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625158/
https://www.ncbi.nlm.nih.gov/pubmed/28971604
http://dx.doi.org/10.1002/prp2.354