Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors

Diallyl sulfide (DAS), a selective inhibitor of CYP2E1, has shown protective effects against alcohol‐ and acetaminophen‐induced hepatotoxicity in many studies. However, DAS is also a CYP2E1 substrate that on metabolism produces toxic metabolites and causes cytotoxicity. The objective of this study w...

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Detalles Bibliográficos
Autores principales: Rahman, Mohammad A., Midde, Narasimha M., Wu, Xiaoxin, Li, Wei, Kumar, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625166/
https://www.ncbi.nlm.nih.gov/pubmed/28971616
http://dx.doi.org/10.1002/prp2.362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625166/
https://www.ncbi.nlm.nih.gov/pubmed/28971616
http://dx.doi.org/10.1002/prp2.362

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