Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
The bromodomain and extra-terminal (BET) family of proteins, comprised of four members including BRD2, BRD3, BRD4 and the testis-specific isoform BRDT, largely function as transcriptional co-activators (1–3) and play critical roles in various cellular processes, including cell cycle, apoptosis, migr...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625299/ https://www.ncbi.nlm.nih.gov/pubmed/28805820 http://dx.doi.org/10.1038/nm.4378 |