Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control i...

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Detalles Bibliográficos
Autores principales: Won, Sangho, Richards, Sarah-Jane, Walker, Marc, Gibson, Matthew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625543/
https://www.ncbi.nlm.nih.gov/pubmed/28989796
http://dx.doi.org/10.1039/c6nh00202a
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author Won, Sangho
Richards, Sarah-Jane
Walker, Marc
Gibson, Matthew I.
author_facet Won, Sangho
Richards, Sarah-Jane
Walker, Marc
Gibson, Matthew I.
author_sort Won, Sangho
collection PubMed
description Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.
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spelling pubmed-56255432017-10-06 Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition Won, Sangho Richards, Sarah-Jane Walker, Marc Gibson, Matthew I. Nanoscale Horiz Chemistry Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric ‘gates’ to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition. Royal Society of Chemistry 2017-03-01 2016-12-14 /pmc/articles/PMC5625543/ /pubmed/28989796 http://dx.doi.org/10.1039/c6nh00202a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Won, Sangho
Richards, Sarah-Jane
Walker, Marc
Gibson, Matthew I.
Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title_full Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title_fullStr Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title_full_unstemmed Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title_short Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
title_sort externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625543/
https://www.ncbi.nlm.nih.gov/pubmed/28989796
http://dx.doi.org/10.1039/c6nh00202a
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AT walkermarc externallycontrollableglycanpresentationonnanoparticlesurfacestomodulatelectinrecognition
AT gibsonmatthewi externallycontrollableglycanpresentationonnanoparticlesurfacestomodulatelectinrecognition

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