RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses

BACKGROUND: F-box and WD40 repeat domain-containing 7 (FBXW7) is an E3 ubiquitin ligase involved in the ubiquitination and degradation of multiple oncogenic substrates. The tumour suppressor function is frequently lost in multiple cancers through genetic deletion and mutations in a broad range of tu...

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Detalles Bibliográficos
Autores principales: Dolly, Saoirse O, Gurden, Mark D, Drosopoulos, Konstantinos, Clarke, Paul, de Bono, Johann, Kaye, Stan, Workman, Paul, Linardopoulos, Spiros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625678/
https://www.ncbi.nlm.nih.gov/pubmed/28829765
http://dx.doi.org/10.1038/bjc.2017.277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625678/
https://www.ncbi.nlm.nih.gov/pubmed/28829765
http://dx.doi.org/10.1038/bjc.2017.277

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