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Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease
Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium sagittatum, has shown promise in the treatment and prevention of Alzheimer's disease. Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechani...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625750/ https://www.ncbi.nlm.nih.gov/pubmed/29057264 http://dx.doi.org/10.1155/2017/7464872 |
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author | Sheng, Chenxia Xu, Panpan Zhou, Kexin Deng, Dan Zhang, Chunhu Wang, Zhe |
author_facet | Sheng, Chenxia Xu, Panpan Zhou, Kexin Deng, Dan Zhang, Chunhu Wang, Zhe |
author_sort | Sheng, Chenxia |
collection | PubMed |
description | Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium sagittatum, has shown promise in the treatment and prevention of Alzheimer's disease. Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechanism driving the learning and memory deficits present in patients with Alzheimer's disease. This study investigated the neuroprotective effects of icariin in an Aβ(1–42)-induced rat model of Alzheimer's disease. Our results showed that Aβ(1–42) injection induced loss of learning and memory behaviour in the Morris water maze, which could be reversed with intragastric administration of ICA. Furthermore, ICA reversed decreases in PSD-95, BDNF, pTrkB, pAkt, and pCREB expressions and prevented deterioration of synaptic interface structure. These findings indicate that ICA may improve synaptic plasticity through the BDNF/TrkB/Akt pathway and provide further evidence for its clinical application to improve learning and memory in patients with Alzheimer's disease. |
format | Online Article Text |
id | pubmed-5625750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56257502017-10-22 Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease Sheng, Chenxia Xu, Panpan Zhou, Kexin Deng, Dan Zhang, Chunhu Wang, Zhe Biomed Res Int Research Article Icariin (ICA), a prenylated flavanol glycoside present in abundant quantities in Epimedium sagittatum, has shown promise in the treatment and prevention of Alzheimer's disease. Damage to synaptic plasticity induced by amyloid-beta-mediated neurotoxicity is considered a main pathological mechanism driving the learning and memory deficits present in patients with Alzheimer's disease. This study investigated the neuroprotective effects of icariin in an Aβ(1–42)-induced rat model of Alzheimer's disease. Our results showed that Aβ(1–42) injection induced loss of learning and memory behaviour in the Morris water maze, which could be reversed with intragastric administration of ICA. Furthermore, ICA reversed decreases in PSD-95, BDNF, pTrkB, pAkt, and pCREB expressions and prevented deterioration of synaptic interface structure. These findings indicate that ICA may improve synaptic plasticity through the BDNF/TrkB/Akt pathway and provide further evidence for its clinical application to improve learning and memory in patients with Alzheimer's disease. Hindawi 2017 2017-09-19 /pmc/articles/PMC5625750/ /pubmed/29057264 http://dx.doi.org/10.1155/2017/7464872 Text en Copyright © 2017 Chenxia Sheng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sheng, Chenxia Xu, Panpan Zhou, Kexin Deng, Dan Zhang, Chunhu Wang, Zhe Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title | Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title_full | Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title_fullStr | Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title_full_unstemmed | Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title_short | Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ(1–42)-Induced Rat Model of Alzheimer's Disease |
title_sort | icariin attenuates synaptic and cognitive deficits in an aβ(1–42)-induced rat model of alzheimer's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625750/ https://www.ncbi.nlm.nih.gov/pubmed/29057264 http://dx.doi.org/10.1155/2017/7464872 |
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