T cells of Parkinson’s disease patients recognize α–synuclein peptides

Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxi...

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Detalles Bibliográficos
Autores principales: Sulzer, David, Alcalay, Roy N., Garretti, Francesca, Cote, Lucien, Kanter, Ellen, Agin-Liebes, Julian P., Liong, Christopher, McMurtrey, Curtis, Hildebrand, William H., Mao, Xiaobo, Dawson, Valina L., Dawson, Ted M., Oseroff, Carla, Pham, John, Sidney, John, Dillon, Myles B, Carpenter, Chelsea, Weiskopf, Daniela, Phillips, Elizabeth, Mallal, Simon, Peters, Bjoern, Frazier, April, Lindestam Arlehamn, Cecilia S., Sette, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626019/
https://www.ncbi.nlm.nih.gov/pubmed/28636593
http://dx.doi.org/10.1038/nature22815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626019/
https://www.ncbi.nlm.nih.gov/pubmed/28636593
http://dx.doi.org/10.1038/nature22815

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