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T cells of Parkinson’s disease patients recognize α–synuclein peptides
Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626019/ https://www.ncbi.nlm.nih.gov/pubmed/28636593 http://dx.doi.org/10.1038/nature22815 |
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| author | Sulzer, David Alcalay, Roy N. Garretti, Francesca Cote, Lucien Kanter, Ellen Agin-Liebes, Julian P. Liong, Christopher McMurtrey, Curtis Hildebrand, William H. Mao, Xiaobo Dawson, Valina L. Dawson, Ted M. Oseroff, Carla Pham, John Sidney, John Dillon, Myles B Carpenter, Chelsea Weiskopf, Daniela Phillips, Elizabeth Mallal, Simon Peters, Bjoern Frazier, April Lindestam Arlehamn, Cecilia S. Sette, Alessandro |
| author_facet | Sulzer, David Alcalay, Roy N. Garretti, Francesca Cote, Lucien Kanter, Ellen Agin-Liebes, Julian P. Liong, Christopher McMurtrey, Curtis Hildebrand, William H. Mao, Xiaobo Dawson, Valina L. Dawson, Ted M. Oseroff, Carla Pham, John Sidney, John Dillon, Myles B Carpenter, Chelsea Weiskopf, Daniela Phillips, Elizabeth Mallal, Simon Peters, Bjoern Frazier, April Lindestam Arlehamn, Cecilia S. Sette, Alessandro |
| author_sort | Sulzer, David |
| collection | PubMed |
| description | Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in Parkinson’s disease patients. These responses may explain the association of Parkinson’s disease with alleles of the acquired immune system. |
| format | Online Article Text |
| id | pubmed-5626019 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56260192017-12-21 T cells of Parkinson’s disease patients recognize α–synuclein peptides Sulzer, David Alcalay, Roy N. Garretti, Francesca Cote, Lucien Kanter, Ellen Agin-Liebes, Julian P. Liong, Christopher McMurtrey, Curtis Hildebrand, William H. Mao, Xiaobo Dawson, Valina L. Dawson, Ted M. Oseroff, Carla Pham, John Sidney, John Dillon, Myles B Carpenter, Chelsea Weiskopf, Daniela Phillips, Elizabeth Mallal, Simon Peters, Bjoern Frazier, April Lindestam Arlehamn, Cecilia S. Sette, Alessandro Nature Article Genetic studies associate Parkinson’s disease with alleles of the major histocompatibility complex(1–3). We find that a defined set of peptides derived from α-synuclein, a protein aggregated in Parkinson’s disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in Parkinson’s disease patients. These responses may explain the association of Parkinson’s disease with alleles of the acquired immune system. 2017-06-21 2017-06-29 /pmc/articles/PMC5626019/ /pubmed/28636593 http://dx.doi.org/10.1038/nature22815 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Sulzer, David Alcalay, Roy N. Garretti, Francesca Cote, Lucien Kanter, Ellen Agin-Liebes, Julian P. Liong, Christopher McMurtrey, Curtis Hildebrand, William H. Mao, Xiaobo Dawson, Valina L. Dawson, Ted M. Oseroff, Carla Pham, John Sidney, John Dillon, Myles B Carpenter, Chelsea Weiskopf, Daniela Phillips, Elizabeth Mallal, Simon Peters, Bjoern Frazier, April Lindestam Arlehamn, Cecilia S. Sette, Alessandro T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title | T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title_full | T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title_fullStr | T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title_full_unstemmed | T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title_short | T cells of Parkinson’s disease patients recognize α–synuclein peptides |
| title_sort | t cells of parkinson’s disease patients recognize α–synuclein peptides |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626019/ https://www.ncbi.nlm.nih.gov/pubmed/28636593 http://dx.doi.org/10.1038/nature22815 |
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