Cargando…

Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia

This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent genera...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Jia-Hua, Jiang, Wan-Wei, Liao, Ya-Jing, Wang, Qing-Hui, Xu, Min, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626124/
https://www.ncbi.nlm.nih.gov/pubmed/28767570
http://dx.doi.org/10.1097/MD.0000000000007519
_version_ 1783268495015804928
author Cui, Jia-Hua
Jiang, Wan-Wei
Liao, Ya-Jing
Wang, Qing-Hui
Xu, Min
Li, Yu
author_facet Cui, Jia-Hua
Jiang, Wan-Wei
Liao, Ya-Jing
Wang, Qing-Hui
Xu, Min
Li, Yu
author_sort Cui, Jia-Hua
collection PubMed
description This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general intravenous anesthesia. At the end of surgery, each patient in group A was injected with 5 mg (5 mL) of oxycodone hydrochloride, while 5 mg (5 mL) of morphine hydrochloride in group B. Venous blood was withdrawn in both groups at different time points. Changes in the numbers of T lymphocyte subsets and natural killer (NK) cells were determined by flow cytometry. First the numbers of T lymphocyte subsets and NK cells at T1, T2, T3, and T4 decreased in both groups, compared with those at T0, and the differences were statistically significant. Furthermore, the numbers reduced to a minimum at T2 and began to recover at T3. Second the differences between group A and B at T1, T2, T3, and T4 were statistically significant; and the numbers of T lymphocytes and NK cells were higher in group A than in group B at corresponding time points. Oxycodone hydrochloride and morphine hydrochloride both have inhibitory effects on immune function in patients undergoing radical resection of rectal cancer after surgery. However, oxycodone hydrochloride has a smaller effect compared to morphine hydrochloride.
format Online
Article
Text
id pubmed-5626124
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-56261242017-10-11 Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia Cui, Jia-Hua Jiang, Wan-Wei Liao, Ya-Jing Wang, Qing-Hui Xu, Min Li, Yu Medicine (Baltimore) 3300 This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general intravenous anesthesia. At the end of surgery, each patient in group A was injected with 5 mg (5 mL) of oxycodone hydrochloride, while 5 mg (5 mL) of morphine hydrochloride in group B. Venous blood was withdrawn in both groups at different time points. Changes in the numbers of T lymphocyte subsets and natural killer (NK) cells were determined by flow cytometry. First the numbers of T lymphocyte subsets and NK cells at T1, T2, T3, and T4 decreased in both groups, compared with those at T0, and the differences were statistically significant. Furthermore, the numbers reduced to a minimum at T2 and began to recover at T3. Second the differences between group A and B at T1, T2, T3, and T4 were statistically significant; and the numbers of T lymphocytes and NK cells were higher in group A than in group B at corresponding time points. Oxycodone hydrochloride and morphine hydrochloride both have inhibitory effects on immune function in patients undergoing radical resection of rectal cancer after surgery. However, oxycodone hydrochloride has a smaller effect compared to morphine hydrochloride. Wolters Kluwer Health 2017-08-04 /pmc/articles/PMC5626124/ /pubmed/28767570 http://dx.doi.org/10.1097/MD.0000000000007519 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 3300
Cui, Jia-Hua
Jiang, Wan-Wei
Liao, Ya-Jing
Wang, Qing-Hui
Xu, Min
Li, Yu
Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title_full Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title_fullStr Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title_full_unstemmed Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title_short Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
title_sort effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
topic 3300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626124/
https://www.ncbi.nlm.nih.gov/pubmed/28767570
http://dx.doi.org/10.1097/MD.0000000000007519
work_keys_str_mv AT cuijiahua effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia
AT jiangwanwei effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia
AT liaoyajing effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia
AT wangqinghui effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia
AT xumin effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia
AT liyu effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia