Cargando…
Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia
This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent genera...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626124/ https://www.ncbi.nlm.nih.gov/pubmed/28767570 http://dx.doi.org/10.1097/MD.0000000000007519 |
_version_ | 1783268495015804928 |
---|---|
author | Cui, Jia-Hua Jiang, Wan-Wei Liao, Ya-Jing Wang, Qing-Hui Xu, Min Li, Yu |
author_facet | Cui, Jia-Hua Jiang, Wan-Wei Liao, Ya-Jing Wang, Qing-Hui Xu, Min Li, Yu |
author_sort | Cui, Jia-Hua |
collection | PubMed |
description | This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general intravenous anesthesia. At the end of surgery, each patient in group A was injected with 5 mg (5 mL) of oxycodone hydrochloride, while 5 mg (5 mL) of morphine hydrochloride in group B. Venous blood was withdrawn in both groups at different time points. Changes in the numbers of T lymphocyte subsets and natural killer (NK) cells were determined by flow cytometry. First the numbers of T lymphocyte subsets and NK cells at T1, T2, T3, and T4 decreased in both groups, compared with those at T0, and the differences were statistically significant. Furthermore, the numbers reduced to a minimum at T2 and began to recover at T3. Second the differences between group A and B at T1, T2, T3, and T4 were statistically significant; and the numbers of T lymphocytes and NK cells were higher in group A than in group B at corresponding time points. Oxycodone hydrochloride and morphine hydrochloride both have inhibitory effects on immune function in patients undergoing radical resection of rectal cancer after surgery. However, oxycodone hydrochloride has a smaller effect compared to morphine hydrochloride. |
format | Online Article Text |
id | pubmed-5626124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-56261242017-10-11 Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia Cui, Jia-Hua Jiang, Wan-Wei Liao, Ya-Jing Wang, Qing-Hui Xu, Min Li, Yu Medicine (Baltimore) 3300 This study aims to explore the effect of oxycodone hydrochloride injection on the immune function of patients who underwent radical resection of rectal cancer under general anesthesia. Eighty patients were enrolled and randomly divided into group A and B (n = 40, each). All patients underwent general intravenous anesthesia. At the end of surgery, each patient in group A was injected with 5 mg (5 mL) of oxycodone hydrochloride, while 5 mg (5 mL) of morphine hydrochloride in group B. Venous blood was withdrawn in both groups at different time points. Changes in the numbers of T lymphocyte subsets and natural killer (NK) cells were determined by flow cytometry. First the numbers of T lymphocyte subsets and NK cells at T1, T2, T3, and T4 decreased in both groups, compared with those at T0, and the differences were statistically significant. Furthermore, the numbers reduced to a minimum at T2 and began to recover at T3. Second the differences between group A and B at T1, T2, T3, and T4 were statistically significant; and the numbers of T lymphocytes and NK cells were higher in group A than in group B at corresponding time points. Oxycodone hydrochloride and morphine hydrochloride both have inhibitory effects on immune function in patients undergoing radical resection of rectal cancer after surgery. However, oxycodone hydrochloride has a smaller effect compared to morphine hydrochloride. Wolters Kluwer Health 2017-08-04 /pmc/articles/PMC5626124/ /pubmed/28767570 http://dx.doi.org/10.1097/MD.0000000000007519 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 3300 Cui, Jia-Hua Jiang, Wan-Wei Liao, Ya-Jing Wang, Qing-Hui Xu, Min Li, Yu Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title | Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title_full | Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title_fullStr | Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title_full_unstemmed | Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title_short | Effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
title_sort | effects of oxycodone on immune function in patients undergoing radical resection of rectal cancer under general anesthesia |
topic | 3300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626124/ https://www.ncbi.nlm.nih.gov/pubmed/28767570 http://dx.doi.org/10.1097/MD.0000000000007519 |
work_keys_str_mv | AT cuijiahua effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia AT jiangwanwei effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia AT liaoyajing effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia AT wangqinghui effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia AT xumin effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia AT liyu effectsofoxycodoneonimmunefunctioninpatientsundergoingradicalresectionofrectalcancerundergeneralanesthesia |