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Gpr158 mediates osteocalcin’s regulation of cognition

That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age. Her...

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Detalles Bibliográficos
Autores principales: Khrimian, Lori, Obri, Arnaud, Ramos-Brossier, Mariana, Rousseaud, Audrey, Moriceau, Stéphanie, Nicot, Anne-Sophie, Mera, Paula, Kosmidis, Stylianos, Karnavas, Theodoros, Saudou, Frederic, Gao, Xiao-Bing, Oury, Franck, Kandel, Eric, Karsenty, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626410/
https://www.ncbi.nlm.nih.gov/pubmed/28851741
http://dx.doi.org/10.1084/jem.20171320