TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency

In the present study, we address the important issue of whether B-cells protected from irradiation-induced cell death, may survive with elevated levels of DNA damage. If so, such cells would be at higher risk of gaining mutations and undergoing malignant transformation. We show that stimulation of B...

Descripción completa

Detalles Bibliográficos
Autores principales: Holm, Kristine Lillebø, Syljuåsen, Randi Gussgard, Hasvold, Grete, Alsøe, Lene, Nilsen, Hilde, Ivanauskiene, Kristina, Collas, Philippe, Shaposhnikov, Sergey, Collins, Andrew, Indrevær, Randi Larsen, Aukrust, Pål, Fevang, Børre, Blomhoff, Heidi Kiil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626471/
https://www.ncbi.nlm.nih.gov/pubmed/28973009
http://dx.doi.org/10.1371/journal.pone.0185708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626471/
https://www.ncbi.nlm.nih.gov/pubmed/28973009
http://dx.doi.org/10.1371/journal.pone.0185708

Ejemplares similares