PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation

Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits...

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Detalles Bibliográficos
Autores principales: Yan, Bing-Ru, Zhou, Lu, Hu, Ming-Ming, Li, Mi, Lin, Heng, Yang, Yan, Wang, Yan-Yi, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626498/
https://www.ncbi.nlm.nih.gov/pubmed/28934360
http://dx.doi.org/10.1371/journal.ppat.1006648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626498/
https://www.ncbi.nlm.nih.gov/pubmed/28934360
http://dx.doi.org/10.1371/journal.ppat.1006648

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