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PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation
Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626498/ https://www.ncbi.nlm.nih.gov/pubmed/28934360 http://dx.doi.org/10.1371/journal.ppat.1006648 |