Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity

Oligomeric Amyloid β(1–42) (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational...

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Detalles Bibliográficos
Autores principales: Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://www.ncbi.nlm.nih.gov/pubmed/28877993
http://dx.doi.org/10.1083/jcb.201701045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://www.ncbi.nlm.nih.gov/pubmed/28877993
http://dx.doi.org/10.1083/jcb.201701045

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