Identification of key regions and residues controlling Aβ folding and assembly

Amyloid β-protein (Aβ) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer’s disease (AD). We used an unbiased D-amino acid substitution strategy to determine structure-assembly relationships of 76 different Aβ40 and Aβ42 peptides. We determined the effects of the substitutio...

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Detalles Bibliográficos
Autores principales: Hayden, Eric Y., Hoi, Kimberly K., Lopez, Jasmine, Inayathullah, Mohammed, Condron, Margaret M., Teplow, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626695/
https://www.ncbi.nlm.nih.gov/pubmed/28974765
http://dx.doi.org/10.1038/s41598-017-10845-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626695/
https://www.ncbi.nlm.nih.gov/pubmed/28974765
http://dx.doi.org/10.1038/s41598-017-10845-6

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