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Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy

Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both...

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Detalles Bibliográficos
Autores principales: Salker, Madhuri S., Singh, Yogesh, Zeng, Ni, Chen, Hong, Zhang, Shaqiu, Umbach, Anja T, Fakhri, Hajar, Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Durairaj, Ruban R. Peter, Barros, Flavio S. V., Vrljicak, Pavle, Ott, Sascha, Brucker, Sara Y, Wallwiener, Diethelm, Vrhovac Madunić, Ivana, Breljak, Davorka, Sabolić, Ivan, Koepsell, Hermann, Brosens, Jan J., Lang, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626729/
https://www.ncbi.nlm.nih.gov/pubmed/28974690
http://dx.doi.org/10.1038/s41598-017-11674-3