NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

NF-κB signaling is essential for osteoclast differentiation and skeletal homeostasis. We have reported recently that NUMB-like (NUMBL) protein modulates osteoclastogenesis by down regulating NF-κB activation. Herein, we decipher the mechanism underlying this phenomenon. We found that whereas NUMBL m...

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Detalles Bibliográficos
Autores principales: Swarnkar, Gaurav, Chen, Tim Hung-Po, Arra, Manoj, Nasir, Amjad M., Mbalaviele, Gabriel, Abu-Amer, Yousef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626749/
https://www.ncbi.nlm.nih.gov/pubmed/28974699
http://dx.doi.org/10.1038/s41598-017-12707-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626749/
https://www.ncbi.nlm.nih.gov/pubmed/28974699
http://dx.doi.org/10.1038/s41598-017-12707-7

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