Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For...

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Detalles Bibliográficos
Autores principales: Bertrand, Nicolas, Grenier, Philippe, Mahmoudi, Morteza, Lima, Eliana M., Appel, Eric A., Dormont, Flavio, Lim, Jong-Min, Karnik, Rohit, Langer, Robert, Farokhzad, Omid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626760/
https://www.ncbi.nlm.nih.gov/pubmed/28974673
http://dx.doi.org/10.1038/s41467-017-00600-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626760/
https://www.ncbi.nlm.nih.gov/pubmed/28974673
http://dx.doi.org/10.1038/s41467-017-00600-w

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