PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8(+) T Cells

Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about the direct impact of PI3Kδ blockade on effector T c...

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Detalles Bibliográficos
Autores principales: Bowers, Jacob S., Majchrzak, Kinga, Nelson, Michelle H., Aksoy, Bulent Arman, Wyatt, Megan M., Smith, Aubrey S., Bailey, Stefanie R., Neal, Lillian R., Hammerbacher, Jeffrey E., Paulos, Chrystal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626814/
https://www.ncbi.nlm.nih.gov/pubmed/29033940
http://dx.doi.org/10.3389/fimmu.2017.01221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626814/
https://www.ncbi.nlm.nih.gov/pubmed/29033940
http://dx.doi.org/10.3389/fimmu.2017.01221

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