Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8(+) T Cell Responses to Chronic Viral Infections and Cancer

In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called “immune checkpoints” by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immu...

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Detalles Bibliográficos
Autores principales: Okoye, Isobel S., Houghton, Michael, Tyrrell, Lorne, Barakat, Khaled, Elahi, Shokrollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626929/
https://www.ncbi.nlm.nih.gov/pubmed/29033936
http://dx.doi.org/10.3389/fimmu.2017.01215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626929/
https://www.ncbi.nlm.nih.gov/pubmed/29033936
http://dx.doi.org/10.3389/fimmu.2017.01215

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