Cargando…

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8(+) T Cell Responses to Chronic Viral Infections and Cancer

In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called “immune checkpoints” by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okoye, Isobel S., Houghton, Michael, Tyrrell, Lorne, Barakat, Khaled, Elahi, Shokrollah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626929/ https://www.ncbi.nlm.nih.gov/pubmed/29033936 http://dx.doi.org/10.3389/fimmu.2017.01215

Ejemplares similares

Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8(+) T cells of HIV-infected individuals
por: Shahbaz, Shima, et al.
Publicado: (2022)

Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis
por: Tabana, Yasser, et al.
Publicado: (2021)

Influence of T Cell Coinhibitory Molecules on CD8(+) Recall Responses
por: Morris, Anna B., et al.
Publicado: (2018)

Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females
por: Mashhouri, Siavash, et al.
Publicado: (2021)

Coinhibitory Molecules in Autoimmune Diseases
por: Watanabe, Norihiko, et al.
Publicado: (2012)

CD71(+) erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors
por: Bozorgmehr, Najmeh, et al.
Publicado: (2023)

Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling
por: Okoye, Isobel, et al.
Publicado: (2017)

PRRSV-1 induced lung lesion is associated with an imbalance between costimulatory and coinhibitory immune checkpoints
por: Ruedas-Torres, Inés, et al.
Publicado: (2023)

Expanded antigen-experienced CD160(+)CD8(+)effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia
por: Bozorgmehr, Najmeh, et al.
Publicado: (2021)

The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance
por: McGrath, Martina M., et al.
Publicado: (2012)

Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4(+) T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer
por: Okoye, Isobel, et al.
Publicado: (2021)

Costimulatory and coinhibitory immune checkpoint receptors in head and neck cancer: unleashing immune responses through therapeutic combinations
por: Davis, Ruth J., et al.
Publicado: (2016)

T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases
por: Lichtman, Andrew H.
Publicado: (2012)

The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections
por: Yasuma-Mitobe, Keiko, et al.
Publicado: (2018)

Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors
por: Okoye, Isobel, et al.
Publicado: (2020)

Costimulatory and coinhibitory molecules of B7-CD28 family in cardiovascular atherosclerosis: A review
por: Yang, Mao, et al.
Publicado: (2022)

Depletion of polyfunctional CD26(high)CD8(+) T cells repertoire in chronic lymphocytic leukemia
por: Bozorgmehr, Najmeh, et al.
Publicado: (2023)

Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
por: Normark, Staffan, et al.
Publicado: (2002)

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis
por: Saito, Suguru, et al.
Publicado: (2022)

Impact of checkpoint blockade on cancer vaccine–activated CD8(+) T cell responses
por: Santos, Patricia M., et al.
Publicado: (2020)

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8(+) T-cell activation and exhaustion
por: Belizário, José, et al.
Publicado: (2020)

Autoantigen-Harboring Apoptotic Cells Hijack the Coinhibitory Pathway of T Cell Activation
por: Yakoub, Abraam M., et al.
Publicado: (2018)

Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses
por: Patsoukis, Nikolaos, et al.
Publicado: (2017)

Selective Upregulation of CTLA-4 on CD8(+) T Cells Restricted by HLA-B*35Px Renders them to an Exhausted Phenotype in HIV-1 infection
por: Elahi, Shokrollah, et al.
Publicado: (2020)

TNF Blockade Maintains an IL-10(+) Phenotype in Human Effector CD4(+) and CD8(+) T Cells
por: Roberts, Ceri A., et al.
Publicado: (2017)

Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
por: Shahbaz, Shima, et al.
Publicado: (2023)

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
por: Leclerc, Marine, et al.
Publicado: (2019)

Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders
por: Zhou, Liye, et al.
Publicado: (2022)

The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
por: Liao, Peng, et al.
Publicado: (2019)

Immunological consequences of extramedullary erythropoiesis: immunoregulatory functions of CD71(+) erythroid cells
por: Elahi, Shokrollah, et al.
Publicado: (2020)

Zika virus oncolytic activity requires CD8(+) T cells and is boosted by immune checkpoint blockade
por: Nair, Sharmila, et al.
Publicado: (2021)

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells
por: Sumida, Tomokazu S., et al.
Publicado: (2020)

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells
por: Hafler, David, et al.
Publicado: (2021)

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells
por: Sumida, Tomokazu S., et al.
Publicado: (2022)

FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer
por: Guan, Yue, et al.
Publicado: (2020)

Cancer-Associated Fibroblasts Suppress CD8(+) T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
por: Jenkins, Liam, et al.
Publicado: (2022)

Galectin-9 promotes natural killer cells activity via interaction with CD44
por: Rahmati, Amirhossein, et al.
Publicado: (2023)

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
por: Santer, Deanna M., et al.
Publicado: (2020)

Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules
por: Gannavaram, Sreenivas, et al.
Publicado: (2016)

Microbiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy
por: Park, Joon Seok, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b07cr2feke0c0k0c8mh0nqv42l