TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2(∗) (α6β2-containing), α4β2(∗), and α3β4(∗) nAChRs, using [(125)I]-epibatidine binding, whole-cell patch-clamp rec...

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Detalles Bibliográficos
Autores principales: Wall, Teagan R., Henderson, Brandon J., Voren, George, Wageman, Charles R., Deshpande, Purnima, Cohen, Bruce N., Grady, Sharon R., Marks, Michael J., Yohannes, Daniel, Kenny, Paul J., Bencherif, Merouane, Lester, Henry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626944/
https://www.ncbi.nlm.nih.gov/pubmed/29033834
http://dx.doi.org/10.3389/fphar.2017.00641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626944/
https://www.ncbi.nlm.nih.gov/pubmed/29033834
http://dx.doi.org/10.3389/fphar.2017.00641

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