Cargando…
TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2(∗) (α6β2-containing), α4β2(∗), and α3β4(∗) nAChRs, using [(125)I]-epibatidine binding, whole-cell patch-clamp rec...
Autores principales: | Wall, Teagan R., Henderson, Brandon J., Voren, George, Wageman, Charles R., Deshpande, Purnima, Cohen, Bruce N., Grady, Sharon R., Marks, Michael J., Yohannes, Daniel, Kenny, Paul J., Bencherif, Merouane, Lester, Henry A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626944/ https://www.ncbi.nlm.nih.gov/pubmed/29033834 http://dx.doi.org/10.3389/fphar.2017.00641 |
Ejemplares similares
-
Modulation of dopamine release by α7-type nicotinic acetylcholine receptors
por: Maex, Reinoud, et al.
Publicado: (2013) -
Deletion of lynx1 reduces the function of α6* nicotinic receptors
por: Parker, Rell L., et al.
Publicado: (2017) -
Selective Ligand Behaviors Provide New Insights into
Agonist Activation of Nicotinic Acetylcholine Receptors
por: Marotta, Christopher B., et al.
Publicado: (2014) -
Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex
por: McClure-Begley, Tristan D., et al.
Publicado: (2016) -
Exploring the Nicotinic Acetylcholine Receptor-associated Proteome with iTRAQ and Transgenic Mice
por: McClure-Begley, Tristan D., et al.
Publicado: (2013)