Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity

Cisplatin has been regarded as an effective and versatile chemotherapeutic agent for nearly 40 years. Though the associated dose-dependent ototoxicity is known, the cellular mechanisms by which cochleovestibular hair cell death occur are not well understood. We have previously shown that aminoglycos...

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Detalles Bibliográficos
Autores principales: Nicholas, Brian D., Francis, Shimon, Wagner, Elizabeth L., Zhang, Sibo, Shin, Jung-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627031/
https://www.ncbi.nlm.nih.gov/pubmed/29033791
http://dx.doi.org/10.3389/fncel.2017.00303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627031/
https://www.ncbi.nlm.nih.gov/pubmed/29033791
http://dx.doi.org/10.3389/fncel.2017.00303

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