Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole

Nifurtimox (Nfx) and benznidazole (Bz) are the current drugs used for the treatment of Chagas disease. The mechanisms of action and resistance to these drugs in this parasite are poorly known. Prostaglandin F2α synthase or old yellow enzyme (OYE), an NAD(P)H flavin oxidoreductase, has been involved...

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Detalles Bibliográficos
Autores principales: García-Huertas, Paola, Mejía-Jaramillo, Ana María, Machado, Carlos Renato, Guimarães, Anna Cláudia, Triana-Chávez, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2017
Materias:
Cellular and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627119/
https://www.ncbi.nlm.nih.gov/pubmed/28989779
http://dx.doi.org/10.1098/rsos.170773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627119/
https://www.ncbi.nlm.nih.gov/pubmed/28989779
http://dx.doi.org/10.1098/rsos.170773

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