Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis

This study aimed to establish a therapeutic strategy targeting hypoxic cancer cells in gastric carcinoma (GC). YC-1 is a HIF-1α inhibitor, and we revealed that low-dose YC-1 (10 µM) suppressed HIF-1α expression, and induced hypoxia-dependent apoptosis in the GC cell line 58As9. This hypoxia-specific...

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Detalles Bibliográficos
Autores principales: Wakiyama, Kota, Kitajima, Yoshihiko, Tanaka, Tomokazu, Kaneki, Masao, Yanagihara, Kazuyoshi, Aishima, Shinichi, Nakamura, Jun, Noshiro, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627264/
https://www.ncbi.nlm.nih.gov/pubmed/28978999
http://dx.doi.org/10.1038/s41598-017-12929-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627264/
https://www.ncbi.nlm.nih.gov/pubmed/28978999
http://dx.doi.org/10.1038/s41598-017-12929-9

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