Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4’-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System A...

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Detalles Bibliográficos
Autores principales: Coccia, Margherita, Collignon, Catherine, Hervé, Caroline, Chalon, Aurélie, Welsby, Iain, Detienne, Sophie, van Helden, Mary J., Dutta, Sheetij, Genito, Christopher J., Waters, Norman C., Van Deun, Katrijn, Smilde, Age K., van den Berg, Robert A., Franco, David, Bourguignon, Patricia, Morel, Sandra, Garçon, Nathalie, Lambrecht, Bart N., Goriely, Stanislas, van der Most, Robbert, Didierlaurent, Arnaud M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627273/
https://www.ncbi.nlm.nih.gov/pubmed/29263880
http://dx.doi.org/10.1038/s41541-017-0027-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627273/
https://www.ncbi.nlm.nih.gov/pubmed/29263880
http://dx.doi.org/10.1038/s41541-017-0027-3

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