Cargando…

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4’-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coccia, Margherita, Collignon, Catherine, Hervé, Caroline, Chalon, Aurélie, Welsby, Iain, Detienne, Sophie, van Helden, Mary J., Dutta, Sheetij, Genito, Christopher J., Waters, Norman C., Van Deun, Katrijn, Smilde, Age K., van den Berg, Robert A., Franco, David, Bourguignon, Patricia, Morel, Sandra, Garçon, Nathalie, Lambrecht, Bart N., Goriely, Stanislas, van der Most, Robbert, Didierlaurent, Arnaud M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627273/ https://www.ncbi.nlm.nih.gov/pubmed/29263880 http://dx.doi.org/10.1038/s41541-017-0027-3

Ejemplares similares

Author Correction: Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
por: Coccia, Margherita, et al.
Publicado: (2018)

Central Role of CD169(+) Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01
por: Detienne, Sophie, et al.
Publicado: (2016)

Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action
por: Buckley, Paul R., et al.
Publicado: (2019)

Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties
por: Givord, Charlotte, et al.
Publicado: (2018)

Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
por: Welsby, Iain, et al.
Publicado: (2017)

Not Just a Sum? Identifying Different Types of Interplay between Constituents in Combined Interventions
por: Van Deun, Katrijn, et al.
Publicado: (2015)

A structured overview of simultaneous component based data integration
por: Van Deun, Katrijn, et al.
Publicado: (2009)

Integrating functional genomics data using maximum likelihood based simultaneous component analysis
por: van den Berg, Robert A, et al.
Publicado: (2009)

CCR2- and Flt3-Dependent Inflammatory Conventional Type 2 Dendritic Cells Are Necessary for the Induction of Adaptive Immunity by the Human Vaccine Adjuvant System AS01
por: Bosteels, Cedric, et al.
Publicado: (2021)

Systems serology-based comparison of antibody effector functions induced by adjuvanted vaccines to guide vaccine design
por: Loos, Carolin, et al.
Publicado: (2023)

Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants
por: Budroni, Sonia, et al.
Publicado: (2021)

Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial
por: van den Berg, Robert A., et al.
Publicado: (2017)

Modeling adaptive response profiles in a vaccine clinical trial
por: Hasdemir, Dicle, et al.
Publicado: (2020)

Subsequent AS01-adjuvanted vaccinations induce similar transcriptional responses in populations with different disease statuses
por: Coccia, Margherita, et al.
Publicado: (2022)

Innate Immune Responses to Chimpanzee Adenovirus Vector 155 Vaccination in Mice and Monkeys
por: Collignon, Catherine, et al.
Publicado: (2020)

DISCO-SCA and Properly Applied GSVD as Swinging Methods to Find Common and Distinctive Processes
por: Van Deun, Katrijn, et al.
Publicado: (2012)

Protective antibody threshold of RTS,S/AS01 malaria vaccine correlates antigen and adjuvant dose in mouse model
por: Genito, Christopher J., et al.
Publicado: (2023)

Responses to A(H1N1)pdm09 Influenza Vaccines in Participants Previously Vaccinated With Seasonal Influenza Vaccine: A Randomized, Observer-Blind, Controlled Study
por: Roy-Ghanta, Sumita, et al.
Publicado: (2014)

RegularizedSCA: Regularized simultaneous component analysis of multiblock data in R
por: Gu, Zhengguo, et al.
Publicado: (2018)

Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine
por: Moris, Philippe, et al.
Publicado: (2017)

Vaccination as a preventative measure contributing to immune fitness
por: Laupèze, Béatrice, et al.
Publicado: (2021)

Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette–Guérin-Vaccinated Adults
por: van den Berg, Robert A., et al.
Publicado: (2018)

Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans
por: Burny, Wivine, et al.
Publicado: (2017)

Revealing the Joint Mechanisms in Traditional Data Linked With Big Data
por: de Schipper, Niek C., et al.
Publicado: (2019)

Bayesian Multilevel Latent Class Models for the Multiple Imputation of Nested Categorical Data
por: Vidotto, Davide, et al.
Publicado: (2018)

Multiple imputation of longitudinal categorical data through bayesian mixture latent Markov models
por: Vidotto, Davide, et al.
Publicado: (2019)

Simultaneous clustering and variable selection: A novel algorithm and model selection procedure
por: Yuan, Shuai, et al.
Publicado: (2022)

Obtaining insights from high-dimensional data: sparse principal covariates regression
por: Van Deun, Katrijn, et al.
Publicado: (2018)

Variable Selection in the Regularized Simultaneous Component Analysis Method for Multi-Source Data Integration
por: Gu, Zhengguo, et al.
Publicado: (2019)

Ontogeny of Myeloid Cells
por: De Kleer, Ismé, et al.
Publicado: (2014)

“World in motion” – emulsion adjuvants rising to meet the pandemic challenges
por: O’Hagan, Derek T., et al.
Publicado: (2021)

Author Correction: “World in motion” – emulsion adjuvants rising to meet the pandemic challenges
por: O’Hagan, Derek T., et al.
Publicado: (2023)

Commentary on ‘Will vaccination refusal prolong the war on SARS-CoV-2?’
por: Welsby, Philip D
Publicado: (2020)

Joint mapping of genes and conditions via multidimensional unfolding analysis
por: Van Deun, Katrijn, et al.
Publicado: (2007)

Stimulus material selection for the Dutch famous faces test for older adults
por: van den Elzen, Evi H. T., et al.
Publicado: (2023)

Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes
por: Phares, Timothy W., et al.
Publicado: (2017)

UNDERSTANDING AND ADDRESSING IMMUNOSENESCENCE
por: Van Der Most, Robbert
Publicado: (2019)

A Guide for Sparse PCA: Model Comparison and Applications
por: Guerra-Urzola, Rosember, et al.
Publicado: (2021)

No Consistent Evidence of Decreased Exposure to Varicella-Zoster Virus Among Older Adults in Countries with Universal Varicella Vaccination
por: Carryn, Stephane, et al.
Publicado: (2021)

A flexible framework for sparse simultaneous component based data integration
por: Van Deun, Katrijn, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_asgonppqfsdrhag68976gqj7lb