Cargando…

Inflammatory Th17 Cells Express Integrin α(v)β(3) for Pathogenic Function

Inerleukin-23 (IL-23) is required for inflammatory Th17 cell function in experimental autoimmune encephalomyelitis (EAE), and IL-23 blockade reduces the number of effector Th17 cells in the CNS. We report that pro-inflammatory Th17 cells express high integrin β(3) that is IL-23 dependent. Integrin β...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Fang, Garg, Abhishek V., Kosar, Karis, Majumder, Saikat, Kugler, David G., Mir, Gerard Hernandez, Maggio, Maria, Henkel, Matthew, Lacy-Hulbert, Adam, McGeachy, Mandy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627357/ https://www.ncbi.nlm.nih.gov/pubmed/27452457 http://dx.doi.org/10.1016/j.celrep.2016.06.065

Ejemplares similares

CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis
por: Hernandez-Mir, Gerard, et al.
Publicado: (2017)

Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen
por: Poholek, Catherine H., et al.
Publicado: (2020)

The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation
por: Bechara, Rami, et al.
Publicado: (2022)

Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint
por: McGeachy, Mandy J.
Publicado: (2022)

Analysis of CXCR5(+)Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis
por: Singh, Deepika, et al.
Publicado: (2016)

The metabolism-modulating activity of IL-17 signaling in health and disease
por: Bechara, Rami, et al.
Publicado: (2021)

Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling
por: Ghoreschi, Kamran, et al.
Publicado: (2010)

Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses
por: Bishu, Shrinivas, et al.
Publicado: (2014)

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism
por: Whibley, Natasha, et al.
Publicado: (2015)

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections
por: Conti, Heather R., et al.
Publicado: (2014)

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
por: Boniface, Katia, et al.
Publicado: (2009)

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly
por: Sidrauski, Carmela, et al.
Publicado: (2015)

Temporary consumption of western diet trains the immune system to reduce future gut inflammation
por: Wu, Dongwen, et al.
Publicado: (2023)

Apoptotic Cell–Directed Resolution of Lung Inflammation Requires Myeloid αv Integrin–Mediated Induction of Regulatory T Lymphocytes
por: Zhang, Ailiang, et al.
Publicado: (2020)

Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin α(v) and TGF-β activation
por: Zhang, Ailiang, et al.
Publicado: (2020)

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina
por: Hirota, Shinya, et al.
Publicado: (2011)

Endogenous Interleukin-17a Contributes to Normal Spatial Memory Retention but Does Not Affect Early Behavioral or Neuropathological Outcomes after Experimental Traumatic Brain Injury
por: Simon, Dennis W., et al.
Publicado: (2022)

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
por: Ahern, Philip P., et al.
Publicado: (2010)

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
por: Ahern, Philip P., et al.
Publicado: (2011)

Verification of Acuros XB dose algorithm using 3D printed low‐density phantoms for clinical photon beams
por: Zavan, Rodolfo, et al.
Publicado: (2018)

Development of a Machine Learning Model for Optimal Applicator Selection in High-Dose-Rate Cervical Brachytherapy
por: Stenhouse, Kailyn, et al.
Publicado: (2021)

Corrigendum: Development of a Machine Learning Model for Optimal Applicator Selection in High-Dose-Rate Cervical Brachytherapy
por: Stenhouse, Kailyn, et al.
Publicado: (2021)

Surveying the global landscape of post-transcriptional regulators
por: Reynaud, Kendra, et al.
Publicado: (2023)

The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver
por: Biswas, Atreyi, et al.
Publicado: (2020)

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
por: Khurana, Satish, et al.
Publicado: (2016)

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
por: Rothhammer, Veit, et al.
Publicado: (2011)

Proximal and Distal Regions of Pathogenic Th17 Related Chromatin Loci Are Sequentially Accessible During Pathogenicity of Th17
por: Hu, Luni, et al.
Publicado: (2022)

Comparing sea ice habitat fragmentation metrics using integrated step selection analysis
por: Biddlecombe, Brooke A., et al.
Publicado: (2020)

MRI‐TRUS registration methodology for TRUS‐guided HDR prostate brachytherapy
por: McGeachy, Philip, et al.
Publicado: (2021)

Smooth muscle α(v) integrins regulate vascular fibrosis via CD109 downregulation of TGF-β signalling
por: Li, Zhenlin, et al.
Publicado: (2023)

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
por: Marwaha, Ashish K., et al.
Publicado: (2012)

Counting charges on membrane-bound peptides
por: McGeachy, Alicia C., et al.
Publicado: (2018)

A modern mold room: Meshing 3D surface scanning, digital design, and 3D printing with bolus fabrication
por: Sasaki, David Kiyoshi, et al.
Publicado: (2019)

Influence of sea ice dynamics on population energetics of Western Hudson Bay polar bears
por: Johnson, Amy C, et al.
Publicado: (2020)

Loss of Epithelial p53 and αv Integrin Cooperate through Akt to Induce Squamous Cell Carcinoma yet Prevent Remodeling of the Tumor Microenvironment
por: Savar, Aaron, et al.
Publicado: (2014)

Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis
por: Vitales-Noyola, Marlen, et al.
Publicado: (2022)

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
por: Acharya, Mridu, et al.
Publicado: (2016)

Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases
por: Wu, Xinyu, et al.
Publicado: (2018)

Reprogramming in vivo th17 into th17/th2 by Sirp-α dendritic cells in the lungs
por: Quang Van, Vu, et al.
Publicado: (2011)

NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells
por: Babic, Marina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o3uua90jtso8cv3mns4prp5rhb