Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers

BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is amplified and a clinical target in a subset of human breast cancers with high rates of metastasis. Targeted therapies involving the antibody trastuzumab and trastuzumab-emtansine (T-DM1) have greatly improved outcomes for HER2-positive (...

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Detalles Bibliográficos
Autores principales: Baldassarre, Tomas, Truesdell, Peter, Craig, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627411/
https://www.ncbi.nlm.nih.gov/pubmed/28974266
http://dx.doi.org/10.1186/s13058-017-0900-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627411/
https://www.ncbi.nlm.nih.gov/pubmed/28974266
http://dx.doi.org/10.1186/s13058-017-0900-z

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