GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies

The determination of the binding strength of immunoglobulins (IgGs) to targets can be influenced by avidity when the targets are soluble di- or multimeric proteins, or associated to cell surfaces, including surfaces introduced from heterogeneous assays. However, for the understanding of the contribu...

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Detalles Bibliográficos
Autores principales: Moelleken, Jörg, Endesfelder, Manuel, Gassner, Christian, Lingke, Sabine, Tomaschek, Simone, Tyshchuk, Oksana, Lorenz, Stefan, Reiff, Ulrike, Mølhøj, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627592/
https://www.ncbi.nlm.nih.gov/pubmed/28805498
http://dx.doi.org/10.1080/19420862.2017.1364325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627592/
https://www.ncbi.nlm.nih.gov/pubmed/28805498
http://dx.doi.org/10.1080/19420862.2017.1364325

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