A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins

During manufacturing and storage process, therapeutic proteins are subject to various post-translational modifications (PTMs), such as isomerization, deamidation, oxidation, disulfide bond modifications and glycosylation. Certain PTMs may affect bioactivity, stability or pharmacokinetics and pharmac...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Weichen, Jimenez, Rod Brian, Mowery, Rachel, Luo, Haibin, Cao, Mingyan, Agarwal, Nitin, Ramos, Irina, Wang, Xiangyang, Wang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627594/
https://www.ncbi.nlm.nih.gov/pubmed/28805536
http://dx.doi.org/10.1080/19420862.2017.1364326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627594/
https://www.ncbi.nlm.nih.gov/pubmed/28805536
http://dx.doi.org/10.1080/19420862.2017.1364326

Ejemplares similares