Chaperone proteins as single component reagents to assess antibody nonspecificity

Early stage assays that evaluate monoclonal antibody drug-like properties serve as valuable tools for selection of lead candidates. One liability for clinical development, off-target reactivity, is often assessed by binding to a mixture or panel of noncognate proteins. While robust, these mixes are...

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Detalles Bibliográficos
Autores principales: Kelly, Ryan L., Geoghegan, James C., Feldman, Jared, Jain, Tushar, Kauke, Monique, Le, Doris, Zhao, Jessie, Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627595/
https://www.ncbi.nlm.nih.gov/pubmed/28745541
http://dx.doi.org/10.1080/19420862.2017.1356529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627595/
https://www.ncbi.nlm.nih.gov/pubmed/28745541
http://dx.doi.org/10.1080/19420862.2017.1356529

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