Heterocyclic boronic acids display sialic acid selective binding in a hypoxic tumor relevant acidic environment

Boronic acids are well known for their ability to reversibly interact with the diol groups found in sugars and glycoproteins. However, they are generally indiscriminate in their binding. Herein we describe the discovery of a group of heterocyclic boronic acids demonstrating unusually high affinity a...

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Detalles Bibliográficos
Autores principales: Matsumoto, A., Stephenson-Brown, A. J., Khan, T., Miyazawa, T., Cabral, H., Kataoka, K., Miyahara, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627601/
https://www.ncbi.nlm.nih.gov/pubmed/28989647
http://dx.doi.org/10.1039/c7sc01905j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627601/
https://www.ncbi.nlm.nih.gov/pubmed/28989647
http://dx.doi.org/10.1039/c7sc01905j

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